Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  11

Year :  2013

Pages :   985-991

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and QSAR Studies of Some 2,5-Diaryl Substituted-1,3,4-Oxadiazole Derivatives



Address:   R. S. Kalkotwar1* and R. B. Saudagar2
1Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, India
2Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S. India.
*Corresponding Author
DOI No:

ABSTRACT:
A novel series of some substituted 5-diaryl substituted-1,3,4-oxadiazole derivatives were prepared from benzoic acid hydrazones with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. Chemical structures of synthesized compounds were supported by means of IR, 1H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. QSAR for the tittle compounds had been performed using TSAR 3.3 software and results were found satisfactory. Among the synthesized compounds some compounds found to possess all these activities.
KEYWORDS:
QSAR, antibacterial, antifungal, antitubercular, anti-inflammatory activity.
Cite:
R. S. Kalkotwar, R. B. Saudagar. Synthesis and QSAR Studies of Some 2,5-Diaryl Substituted-1,3,4-Oxadiazole Derivatives. Asian J. Research Chem. 6(11): November 2013; Page 985-991.
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