Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  11

Year :  2013

Pages :   1040-1043

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization of Substituted 3-Cyanopyrroles and Evaluation of Antimicrobial Activity.



Address:   Pawar Rupali Rajaram*, Mohite Shrinivas Krishna
R.C.P. Kasegaon, Sangli, (Maharashtra) India., India
*Corresponding Author
DOI No:

ABSTRACT:
A straightforward simple synthesis of substituted 3-cyanopyrroles using Paal–Knorr method has been accomplished with a satisfactory yield. The Paal–Knorr pyrrole synthesis, which involves the reaction of dicarbonyls with amines, is among the most classical methods of heterocyclic pyrrole ring synthesis. The detailed sequence and the nature of the intermediates that occur in the Paal–Knorr reaction mechanism are not well understood. This method produces pyrroles with multicyclic aromatic amines. A series of substituted 3-cyanopyrrole derivatives were evaluated for anti-inflammatory and antimicrobial activity.
KEYWORDS:
Anti-microbial activity, Benzoin, Cyanopyrroles, Pyrrolopyrimidine.
Cite:
Pawar Rupali Rajaram, Mohite Shrinivas Krishna. Synthesis, Characterization of Substituted 3-Cyanopyrroles and Evaluation of Antimicrobial Activity. Asian J. Research Chem. 6(11): November 2013; Page 1040-1043.
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