Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  12

Year :  2013

Pages :   1169-1172

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Absorption Ratio Method for Simultaneous Estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol



Address:   Megha Pancholi , Falguni Tandel*, Nikita Patel
Department of Quality Assurance, Parul Institute of Pharmacy, At. Po. Limda, Ta.Waghodia, Dist. Vadodara, Gujarat, India.
*Corresponding Author
DOI No:

ABSTRACT:
Developed Absorption Ratio Method is a simple, rapid, accurate and robust spectroscopic method for simultaneous estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol in bulk and Synthetic mixture. The wavelengths selected for Absorption ratio method were 260.0 nm (?max of DEX) and 311.5 nm(iso-absorptive point). Linearity range was found to be 14-24 µg/mL for Dicyclomine and 35-60 µg/mL for Dexketoprofen with r2 value more than 0.999. Various validation parameters like linearity-range, precision, accuracy, robustness, LOD and LOQ were checked. % RSD was found to be less than 2 for repeatability and intermediate precision. % Recovery was found 99.025 ± 0.38 and 101.233 ± 0.18 for Dicyclomine Hydrochloride and Dexketoprofen Trometamol respectively. The developed method can be successfully applied for simultaneous estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol.
KEYWORDS:
Absorption Ratio Method, UV-Spectroscopic method, Dicyclomine hydrochloride, Dexketoprofen Trometamol, Simultaneous method.
Cite:
Megha Pancholi , Falguni Tandel, Nikita Patel. Absorption Ratio Method for Simultaneous Estimation of Dicyclomine Hydrochloride and Dexketoprofen Trometamol. Asian J. Research Chem. 6(12): December 2013; Page 1169-1172.
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