Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  2

Year :  2013

Pages :   97-100

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity



Address:   Freddy H. Havaldar* and Azadkumar S. Sharma
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001.
*Corresponding Author
DOI No:

ABSTRACT:
A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino-4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.
KEYWORDS:
Synthesis, Oxadiazole, Antibacterial and antifungal activity.
Cite:
Freddy H. Havaldar, Azadkumar S. Sharma. Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity. Asian J. Research Chem. 6(2): February 2013; Page 97-100.
[View HTML]      [View PDF]



Visitor's No. :   113426