Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  2

Year :  2013

Pages :   155-157

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Diclofenac and Pantoprazole in Combined Capsule Dosage Form



Address:   Khushbu Naik*, Gunjansinh Parmar, Jalpesh Ahiya, Kunjan Bodiwala, Shailesh Shah
Department of Quality Assurance, Maliba Pharmacy College, Bardoli, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
Derivative spectroscopy offers a useful approach for the analysis of drugs in multi-component mixtures. In this study a first-derivative spectroscopic method was used for the simultaneous determination of diclofenac and pantoprazole in combined capsule dosage form using the zero-crossing technique. The wavelengths 290.2 nm and 276.2 nm of first derivative spectrum were selected for the estimation of diclofenac and pantoprazole, respectively without mutual interference. The method was linear in the concentration range 15-75µg/ml and 5-25µg/ml for diclofenac and pantoprazole, respectively. Validation studies confirmed the accuracy and precision of the proposed method. The result of the formulation analysis shows that the proposed method can be successfully used for the simultaneous estimation of both the drugs in their combined capsule dosage form.
KEYWORDS:
Diclofenac, Pantoprazole, Simultaneous determination, Derivative spectrophotometry, Zero crossing point.
Cite:
Khushbu Naik, Gunjansinh Parmar, Jalpesh Ahiya, Kunjan Bodiwala, Shailesh Shah. Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Diclofenac and Pantoprazole in Combined Capsule Dosage Form. Asian J. Research Chem. 6(2): February 2013; Page 155-157.
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