Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  2

Year :  2013

Pages :   177-181

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Substituted Thienopyrimidines and Their Evaluation as Antibacterial

Address:   Rahul More1, J. N. Narendra Sharath Chandra1, Shachindra. L. Nargund2, L.V.G. Nargund1*
1Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreya Nagar, II main, 100 Ft Ring Road, BSK II Stage, Bangalore- 560085(India).
2Department of Chemistry, Texas State University, San Marcos, USA
*Corresponding Author

We have synthesized various substituted thieno(2,3-d)pyrimidines, first by synthesizing ethyl 2-aminothiophene-3-carboxylate (3), by treatment of diethane with ethyl cynoacetate in presence of triethylamine, acetic acid and DMF. Further, the intermediate Ethyl 2-(ethoxycarbonyl)thiophene-3-carboxylate (5) was prepared by compound (3) refluxed with ethyl chloroformate. The key intermediate 3-(3-chloro-4-fluorophenyl) thieno [2, 3-d]pyrimidine-2, 4(1H, 3H)-dione (7) was prepared by cyclisation of compound (5) with 3-chloro-4-fluoro aniline. The nucleophilic substitution of compound 3-(3-chloro-4-fluorophenyl) thieno [2, 3-d]pyrimidine-2, 4(1 H, 3 H)-dione (7) with various aromatic amines(8a-m), aminophenol(8n) gives substituted thienopyrimidines(8a-n). The synthesized new compounds were characterized by MP, TLC, IR and NMR spectra.
Rahul More, J. N. Narendra Sharath Chandra, Shachindra. L. Nargund, L.V.G. Nargund. Synthesis of Substituted Thienopyrimidines and Their Evaluation as Antibacterial. Asian J. Research Chem. 6(2): February 2013; Page 177-181.
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