Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  2

Year :  2013

Pages :   135-138

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Levosulpiride and Esomeprazole in Capsule Dosage Form



Address:   Brijen Vaghela1*, Gunjansinh Parmar2, Shailesh Shah2, Dinesh Shah2
1Department of Pharmaceutical Analysis, Maliba Pharmacy College, Bardoli, Gujarat, India
2Depatment of Quality Assurance, Maliba Pharmacy College, Bardoli, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
The use of first order derivative spectrophotometry allows simultaneous determination of levosulpiride and esomeprazole in fixed dose combination products. The wavelengths 275 nm and 291.5 nm of first derivative spectrum were selected for the estimation of levosulpiride and esomeprazole, respectively without mutual interference. The method was linear in the concentration range 25-125 µg/ml and 5-25 µg/ml for levosulpiride and esomeprazole, respectively. The method was validated in terms of accuracy and precision. The result of the formulation analysis shows that the proposed method can be successfully used for the simultaneous estimation of both the drugs in their combined capsule dosage form.
KEYWORDS:
The use of first order derivative spectrophotometry allows simultaneous determination of levosulpiride and esomeprazole in fixed dose combination products. The wavelengths 275 nm and 291.5 nm of first derivative spectrum were selected for the estimation of levosulpiride and esomeprazole, respectivel
Cite:
Brijen Vaghela, Gunjansinh Parmar, Shailesh Shah, Dinesh Shah. Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Levosulpiride and Esomeprazole in Capsule Dosage Form. Asian J. Research Chem. 6(2): February 2013; Page 135-138.
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