Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  3

Year :  2013

Pages :   244-247

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives



Address:   Shivaji Bhattacharjee, J. Saravanan, S. Mohan, Monica Arora
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author
DOI No:

ABSTRACT:
The novel 2-amino-3-carbethoxy-4- phenyl thiophene was synthesized by using a acetophenone and ethyl cyano acetate and the parent compound was reacted with chloroacetic acid and glacial acetic acid, the chloro compound was then substituted with different substituted primary and secondary amines to obtain a series of title compounds [SBJa 1-8]. All the new title compounds were characterized by spectral data and were screened for CNS depressant activity. In conclusion, it can be inferred that the electron donating groups on the phenyl ring at R of the title compounds influenced the CNS depressant activity.
KEYWORDS:
Synthesis, Thiophene, Manich Base, Characterization, CNS Depressant activity.
Cite:
Shivaji Bhattacharjee, J. Saravanan, S. Mohan, Monica Arora. Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives. Asian J. Research Chem. 6(3): March 2013; Page 244-247.
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