Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  3

Year :  2013

Pages :   195-199

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Novel Efficient Synthetic Strategy for (±)Carvedilol, an Antihypertensive Drug



Address:   Yedukondalu M.1, Sridhar R.2, Basaveswara Rao M.V. 3*
1Department of Chemistry, JNT University, Anantapuram, Andhra Pradesh, India.
2Department of Chemistry, KL University, Vaddeswaram ,Guntur - 522502, A.P, India.
3Department of Chemistry, Krishna University, Machilipatnam - 521 001, India.
*Corresponding Author
DOI No:

ABSTRACT:
A New and alternate simple synthetic strategy of carvedilol, ß-adrenergic blocking agent and its analogs, The key step in this approach is synthesis of 3-(9H-carbazol-4-yloxy)-2-hydroxypropyl 4-methylbenzenesulfonate, it is wished to report towards synthesis of Carvedilol this approach is more efficient , improved overall yield, easy process and to avoid the process impurities.
KEYWORDS:
β-Adrenergic Blocking Agents, antihypertensive efficacy drug Suzuki Coupling, Regioselective Tosylation, Cyclisation, Yields.
Cite:
Yedukondalu M., Sridhar R., Basaveswara Rao M.V. . A Novel Efficient Synthetic Strategy for (±)Carvedilol, an Antihypertensive Drug. Asian J. Research Chem. 6(3): March 2013; Page 195-199.
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