Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  3

Year :  2013

Pages :   209-211

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and Evaluation of 2-Amino 5 -Aryl 1,3,4 Thiadiazole Derivatives



Address:   Arvind Kr. Singh*, Deepika Singh
K.N.I.M.T. Faculty of Pharmacy, Sultanpur Uttar Pradesh-228001
*Corresponding Author
DOI No:

ABSTRACT:
There are various biological activity of thiadiazole derivatives, I opted to synthesize derivatives having 1, 3, 4-thiadiazole nucleus and evaluate them for their antibacterial and anti-inflammatory activity. Various substituted 2 amino 5 aryl 1, 3, 4 thiadiazole derivatives were prepared by reacting various nitro and chloro substituted benzoic acid refluxing with thiosemicarbazide, bromine water ethanol and glacial acetic acid. Derivatives were characterized by FTIR, MASS and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram negative strains (E. coli and P. aeruginosa) and two Gram-positive strains (Bacillus cereus and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined by disc diffusion method. Compounds were evaluated for their anti-inflammatory activity by carageneen method.
KEYWORDS:
1, 3, 4 thiadiazole, antibacterial, anti-inflammatory.
Cite:
Arvind Kr. Singh, Deepika Singh. Synthesis, Characterization and Evaluation of 2-Amino 5 -Aryl 1,3,4 Thiadiazole Derivatives. Asian J. Research Chem. 6(3): March 2013; Page 209-211.
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