Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  5

Year :  2013

Pages :   486-489

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Eco-Friendly Synthesis of Novel Fluorine Containing 1,3,4-Oxadiazoles as Antibacterial and Antifungal Agents



Address:   Ajay N. Mehta, Jayraj Yadav, K.R. Desai*
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
*Corresponding Author
DOI No:

ABSTRACT:
Title compounds of 1,3,4-oxadiazoles derivatives by the ring closure reaction of m-fluorobenzoic acid hydrazide with an aromatic acid and alumina in presence of POCl3 under microwave irradiation. All the newly synthesized compounds were screened for their antibacterial activity against Gram-positive bacteria namely staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their antifungal activity against fungi namely, Candida albicans.
KEYWORDS:
2,5-disubstituted 1,3,4-oxadiazoles, ring closure reaction, antibacterial activity, antifungal activity.
Cite:
Ajay N. Mehta, Jayraj Yadav, K.R. Desai. Eco-Friendly Synthesis of Novel Fluorine Containing 1,3,4-Oxadiazoles as Antibacterial and Antifungal Agents. Asian J. Research Chem. 6(5): May 2013; Page 486-489.
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