Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  5

Year :  2013

Pages :   514-516

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Absorption Correction Method for Simultaneous Spectrophotometric Estimation of Flunarizine Dihydrochloride and Propranolol HCl in Combined Capsule Dosage Form



Address:   Sangita W. Chapke*, Madhuri D. Game
Vidyabharati College of Pharmacy, C.K. Naidu Road, Camp, Amravati-444602(M.S.) INDIA
*Corresponding Author
DOI No:

ABSTRACT:
A new, simple, sensitive, accurate and precise UV - spectrophotometric absorption correction method for simultaneous estimation of flunarizine dihydrochloride and propranolol HCl in capsule dosage form has been developed and validated for accuracy, precision, ruggedness, linearity and range. The wavelengths selected for estimation of drugs were 253.2 nm for flunarizine dihydrochloride and 288.8 nm for propranolol HCl. Linearity for detector response for flunarizine dihydrochloride and propranolol HCl were 1-25 µg/ml and 4-100 µg/ml respectively. The method gives results for high accuracy and high recovery of 99.15±1.37 and 100.02±0.89 for flunarizine dihydrochloride and propranolol HCl respectively. % R.S.D. values for marketed formulation analysis were found to be less than 2 which indicated good precision and reproducibility of the method.
KEYWORDS:
Flunarizine dihydrochloride, Propranolol HCl, Absorption correction method.
Cite:
Sangita W. Chapke, Madhuri D. Game. Absorption Correction Method for Simultaneous Spectrophotometric Estimation of Flunarizine Dihydrochloride and Propranolol HCl in Combined Capsule Dosage Form. Asian J. Research Chem. 6(5): May 2013; Page 514-516.
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