Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  6

Year :  2013

Pages :   599-610

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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1,2,3,4-Tetrahydroquinoline Derivatives and its Significance in Medicinal Chemistry



Address:   Prafulla M Sabale*, Pratik Patel, Prabhjot Kaur
Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, India.
*Corresponding Author
DOI No:

ABSTRACT:
1,2,3,4-Tetrahydroquinoline derivatives are the most important class of compounds in the pharmaceutical and agrochemical industries and play important role in the field of medicinal chemistry with so many Pharmacological activities such as anti-cancer, anti-diabetic, anti-parasitic, anti-inflammatory, anti-oxidant, adrenergic, anti-HIV, anti-alzheimer, anti-hyperlipidemic, activities. The tetrahydroquinoline ring containing system found in numerous biologically active natural products and pharmacologically relevant therapeutic agents and very common structure motif. Because of the significance of these scaffolds in medicinal chemistry, the development of some potent and important amalgams continues to be a very active field in development of a promising target for new drug development. 1,2,3,4-Tetrahydroquinoline is one such important part of pharmacophore and having different pharmacological activities. Here we have introduced different 1,2,3,4-tetrahydroquinoline derivatives which possess different biological activities depends on its types and position of substituted functional groups. This review is summarized to know about the chemistry of different 1,2,3,4-tetrahydroquinoline derivatives along with their pharmacological activities.
KEYWORDS:
1,2,3,4-Tetrahydroquinoline, anti-cancer, anti-cancer, anti-diabetic, anti-parasitic, anti-inflammatory.
Cite:
Prafulla M Sabale, Pratik Patel, Prabhjot Kaur. 1,2,3,4-Tetrahydroquinoline Derivatives and its Significance in Medicinal Chemistry. Asian J. Research Chem. 6(6): June 2013; Page 599-610 .
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