Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  6

Year :  2013

Pages :   523-524

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Dipeptidylpeptidase-4 Inhibitory Activity of Pergularia Daemia (Forsk) – An In-vitro Estimation



Address:   Karthik Dhananjayan1, Arunachalam Sumathy2, Sivanandy Palanisamy3
1Department of Pharmacology, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala
2Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala
3Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, Tamilnadu
*Corresponding Author
DOI No:

ABSTRACT:
Dipeptidylpeptidase-4 is an enzyme involved in the inhibition of GLP-1 (Incretin), which is necessary for stimulation of insulin release. It is one of the enzyme targets for the treatment of type-2 diabetes mellitus. Ethanolic and aqueous extracts of Pergularia demia were investigated for activity using ellman method. Successive concentrations (50mg/ml, 100mg/ml, 200 mg/ml, 400 mg/ml, and 800 mg/ml) of ethanolic and aqueous extracts were prepared and investigated for their inhibitory activity towards dipeptidylpeptidase-4 as per Kojima et al., method. It was found that both extracts exhibited significant activity towards DPP-4 inhibition. Diprotein-A was used as standard and distilled water as control.
KEYWORDS:
Diabetes mellitus, Dipeptidylpeptidase-4, Pergularia demia (Forsk), Enzymes.
Cite:
Karthik Dhananjayan, Arunachalam Sumathy, Sivanandy Palanisamy. Dipeptidylpeptidase-4 Inhibitory Activity of Pergularia Daemia (Forsk) – An In-vitro Estimation. Asian J. Research Chem. 6(6): June 2013; Page 523-524.
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