Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  6

Year :  2013

Pages :   540-545

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization, and Antibacterial Activity of some Chelates in O,N-Donor Coordination Pattern involving Schiff bases derived from 4-Acetyl/Benzoyl-1-(4’-Nitrophenyl)-3-Methyl-2-Pyrazolin-5-one and Sulfamoxole



Address:   Thakar A.S.1*, Friedrich H.B.1 and Joshi K.T.2
1School of Chemistry, University of KwaZulu-Natal, Durban, 4000, South Africa
2Department of Chemistry, Navjivan Science College, Dahod, 389 151, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
The condensation reactions of 4-Acetyl/benzoyl-1-(4’-nitrophenyl)-3-methyl-2-pyrazolin-5-ones condensed with sulfamoxole to form bidentate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML2.2H2O] where M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and L = Ligand L1 and Ligand L2. These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, thermo gravimetric analysis, electronic and infrared spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141–160 °C. These compounds were also screened for their in-vitro antibacterial activity against three bacterial species, namely; Escherichia coli, Bacillus subtilis and Staphylococcus aureus. The metal complexes were found to have greater antibacterial activity than the Schiff base ligands.
KEYWORDS:
Synthesis, Characterization, and Antibacterial Activity of some Chelates in O,N-Donor Coordination Pattern involving Schiff bases derived from 4-Acetyl/Benzoyl-1-(4’-Nitrophenyl)-3-Methyl-2-Pyrazolin-5-one and Sulfamoxole.
Cite:
Thakar A.S., Friedrich H.B., Joshi K.T.. Synthesis, Characterization, and Antibacterial Activity of some Chelates in O,N-Donor Coordination Pattern involving Schiff bases derived from 4-Acetyl/Benzoyl-1-(4’-Nitrophenyl)-3-Methyl-2-Pyrazolin-5-one and Sulfamoxole. Asian J. Research Chem. 6(6): June 2013; Page 540-545.
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