Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  7

Year :  2013

Pages :   638-686

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric (Vierodt’s) Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone-D SR Capsules



Address:   Alagar Raja M.1*, Godavari Swetha1, David Banji1, Gosh S.S.1, Vanitha C.1 , Selva Kumar D.2
1Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India- 508001
2School of Pharmacy, Taylors University, Subang Jaya, Malaysia.
*Corresponding Author
DOI No:

ABSTRACT:
The present method describes simple, sensitive, rapid, accurate, precise and economical Spectrophotometric method for the simultaneous determination of Diclofenac Sodium and Eperisone Hydrochloride in bulk and capsule dosage form. The method is based on the Vierodts Method (simultaneous estimation)for analysis of both the drugs using distilled water as solvent. Diclofenac sodium (DIC) has absorbance maxima at 277 nm and Eperisone hydrochloride (EPE) has absorbance maxima at 255 nm in distilled water. The linearity was obtained in the concentration range of 2-12 µg/mL and 3-18 µg/mL for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The concentrations of these drugs were determined by using vierodts equations. The mean % recovery (w/w%) was 99.3 and 100.3% for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The proposed method was found to be simple and sensitive for the routine quality control application of dosage form of Diclofenac Sodium and Eperisone Hydrochloride. The results of analysis have been validated statistically according to ICH guidelines.
KEYWORDS:
Diclofenac Sodium, Eperisone Hydrochloride, Recovery, Vierodts Method, RAPISONE D SR capsules, Validation, ICH.
Cite:
Alagar Raja M., Godavari Swetha, David Banji, Gosh S.S., Vanitha C., Selva Kumar D.. Spectrophotometric (Vierodt’s) Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone-D SR Capsules. Asian J. Research Chem. 6(7): July 2013; Page 683-686.
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