Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  7

Year :  2013

Pages :   641-644

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Thiazolidinone Derivatives Derived from Pyrazolines for Angiotensin II Inhibition activity



Address:   Naveen Kadian, Prerna Pujari*, Ramesh V., A. R. Bhatt
Department of Pharmaceutical Chemistry, KLE University’s College of Pharmacy, Belgaum-590010, Karnataka, India
*Corresponding Author
DOI No:

ABSTRACT:
The main objective of medicinal chemistry is to synthesize compounds that show promising activity as therapeutic agents with lower toxicity. Thiazolidinone and Pyrazoline derivatives may show different activities such as analgesic, anti-inflammatory, antitubercular activities etc. Mannich base derivatives of Thiazolidinones from Schiff bases have been synthesized by reacting them with previously prepared Pyrazolines from Chalocnes, with the yield ranging from 56% to 71%. The identification and characterization of the prepared compounds were carried out by melting point, TLC, FT-IR, 1H-NMR to ascertain that all prepared compounds were of different chemical nature than the respective parent compound. The synthesized compounds were evaluated for angiotensin II blocking activity and were found to show significant results.
KEYWORDS:
Thiazolidinone, Pyrazoline, Mannich Base, Schiff Bases, Chalcones, Angiotensin II blocking activity.
Cite:
Naveen Kadian, Prerna Pujari, Ramesh V., A. R. Bhatt. Synthesis of Thiazolidinone Derivatives Derived from Pyrazolines for Angiotensin II Inhibition activity. Asian J. Research Chem. 6(7): July 2013; Page 641-644.
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