Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  8

Year :  2013

Pages :   731-734

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -Phenyl-3-Mercapto-1,2,4–Triazoles



Address:   M. Vidyasagar1, B.Srinivas2, P. Parameshwar1, A. Ganesh3, R. Ramesh Kumar1
1Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP, India
2Talla Padmavathi College of Pharmacy, ours, Karimabad, Warangal, AP, India
3Procadence Institute of Pharmaceutical Sciences. Gajwel, Medak,. A.P, India
*Corresponding Author
DOI No:

ABSTRACT:
An efficient method for synthesis of 4 substituted 5 -phenyl - 3- mercapto -1, 2, 4 –triazole, by the mode of ring cleavage of oxadiazoles, nucleophiles are readily attack 5-phenyl 1,3,4- oxadiazole-2 – thiols and they are cleaved by acids and basis, in a reaction, which is the reverse of the ring closure, many nucleophilic ring cleavage reaction are followed by recyclization to give different heterocyclics, we were sysnthsized 5 different compounds and characterized its physical data, spectral analysis by IR and these compounds screened for possible CNS activity.
KEYWORDS:
Triazoles, oxadiazole, Grass behavior study, locomotor activity.
Cite:
M. Vidyasagar, B.Srinivas, P. Parameshwar, A. Ganesh, R. Ramesh Kumar. Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -Phenyl-3-Mercapto-1,2,4–Triazoles. Asian J. Research Chem. 6(8): August 2013; Page 731-734.
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