Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  8

Year :  2013

Pages :   740-744

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A RP-HPLC Method Development and Its Validation for the Simultaneous Estimation of Naproxen and Pantoprazole Sodium in Capsule Dosage Form



Address:   Rubesh Kumar S.*, Usha Sree G., Jayanthi K., Naga Malleswara Babu B., Duganath N., Devanna N.
Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh, India.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, and precise High performance liquid chromatographic method for the analysis of Naproxen and Pantoprazole has been developed and validated for the determination of compounds in commercial pharmaceutical products. The compounds were well separated on a BDS Hypersil C-18 reversed-phase column by use of a mobile phase consisting of Acetonitrile and Mixed Phosphate buffer (pH 6.92) in 45:55(V/V%) ratio, at a flow rate of 1.0 mL/min with detection wavelength at 290 nm. The linearity ranges were 20-120µg. The correlation coefficient was found to be 0.997 and 0.995 for Naproxen and Pantoprazole respectively. The recovery amount was in the range of 99.67-101.39%. The high recovery and low relative standard deviation confirms the suitability of the method for determination of Naproxen and Pantoprazole in capsule dosage forms.
KEYWORDS:
Naproxen, Pantoprazole.
Cite:
Rubesh Kumar S., Usha Sree G., Jayanthi K., Naga Malleswara Babu B., Duganath N., Devanna N.. A RP-HPLC Method Development and Its Validation for the Simultaneous Estimation of Naproxen and Pantoprazole Sodium in Capsule Dosage Form. Asian J. Research Chem. 6(8): August 2013; Page 740-744.
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