Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  8

Year :  2013

Pages :   745-748

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form



Address:   Nisha Choudhary, Inamullah, Sunil Singh*, Jyoti Rai, Surabhi Sharma
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
*Corresponding Author
DOI No:

ABSTRACT:
An accurate, specific and precise new Absorption Ratio method was developed for the simultaneous determination of Lansoprazole and Naproxen. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i. e ?max of Lansoprazole (284nm) and for Naproxen was (271nm) and Iso-absorptive point of both drugs (275nm). The linearity was found to be 10-35µg/ml (r2 =0·999) for NAP and 5-30µg/ml (r 2 =0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15µg/ml and for LAN was 1·7µg/ml. The limit of detection of NAP was found to be 0·04µg/ml and for LAN was 0·5µg/ml. The indicating proposed spectrophotometric method was accurate and precise for estimation of NAP and LAN in tablet dosage form.
KEYWORDS:
Lansoprazole, Naproxen, Iso-absorptive point.
Cite:
Nisha Choudhary, Inamullah, Sunil Singh, Jyoti Rai, Surabhi Sharma. Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form. Asian J. Research Chem. 6(8): August 2013; Page 745-748.
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