Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  9

Year :  2013

Pages :   845-848

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Metformin HCl and Glimepiride in Combined Dosage Form



Address:   Atul Srivastav1*, Preeti Tiwari2, Shishir Maheshwari1
1Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
2HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Metformin HCl and Glimepiride in combined dosage form has been developed. Two wavelengths 233 nm and 228.4 nm were selected for estimation of Metformin HCl and Glimepiride respectively. Acetonitrile was used as solvent for analysis of both the drugs. Linearity was observed in the concentration range of 5-10 µg/ml (r2=0.9992) and 3-18 µg/ml (r2=0.9999) for Metformin HCl and Glimepiride respectively. The method was validated as per ICH guidelines.
KEYWORDS:
Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Metformin HCl and Glimepiride in Combined Dosage Form.
Cite:
Atul Srivastav, Preeti Tiwari, Shishir Maheshwari. Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Metformin HCl and Glimepiride in Combined Dosage Form. Asian J. Research Chem. 6(9): September 2013; Page 845-848.
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