Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  9

Year :  2013

Pages :   808-810

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Determination of Oxcarbazepine in Bulk and Pharmaceutical Formulations



Address:   Ch. Muralikrishna1*, C. Rambabu2
1Department of Chemistry, Adikavi Nannaya University, Rajahmundry,-533105, India.
2Department of Chemistry, Acharya Nagarjuna University, Guntur-521201, India
*Corresponding Author
DOI No:

ABSTRACT:
Two new rapid, simple, sensitive reproducible and economical spectrophotometric methods are described for the determination of Oxcarbazepine (OXC) in bulk form. Both methods are based on the formation of colored complexes due to the action of 4-Amino phenazone and IsoNiconitic Hydrazide on OXC in alcoholic medium. Under optimized conditions, they show an absorption maxima at 440nm (4-AP) and 450nm (INH), with molar absorptivities of 3.824 x104 and 2.838x104 mole- cm- and sand ells sensitivities of 0.08474 and 0.13968 per 0.001 absorbance unit for 4-AP and INH, respectively. The color is stable for 5 min after extraction. In both cases Beers law is obeyed between 2.5-12.5 µg/ ml. The proposed method was successfully extended to bulk and Pharmaceutical dosage forms.
KEYWORDS:
Oxcarbazepine (OXC) 4-amino phenazone (4-AP), Isonicotinic hydrazide (INH), Spectrophotometry, condensation.
Cite:
Ch. Muralikrishna, C. Rambabu. Spectrophotometric Determination of Oxcarbazepine in Bulk and Pharmaceutical Formulations. Asian J. Research Chem. 6(9): September 2013; Page 808-810.
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