Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  1

Year :  2014

Pages :   58-61

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives



Address:   Dipali Uthale*, Dr. S. K. Mohite
Rajarambapu College of Pharmacy, Kasegaon-415409, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
An efficient synthesis of different novel 4,5–diphenyl pyrrole derivatives by the paal- knorr condensation has been accomplished using substituted aniline and 1,4 – diketone. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR. The pyrrole derivatives examined for their in vitro antimicrobial activity and in vivo anti- inflammatory. Result indicated that these compounds showed promising anti microbial and anti- inflammatory activity in comparison to amoxicillin and ibuprofen (the standard antimicrobial and anti–inflammatory drugs). Tolmetin (Rumatol) and Ketorolac (Ketolac), nonsteroidal anti-inflammatory drugs (NSAIDs) containing pyrrole ring, are nonselective inhibitors of cyclooxygenase 1 and 2 enzymes that led to decrease prostaglandin synthesis.
KEYWORDS:
Paal- knorr condensation, Pyrrole derivatives, anti-inflammatory.
Cite:
Dipali Uthale, S. K. Mohite. Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives. Asian J. Research Chem 7(1): January 2014; Page 58-61.
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