Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  1

Year :  2014

Pages :   92-98

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Antifungal and Anthelmintic Activity of Some Novel Pyrazole Derivative



Address:   Pratap Kumar Patra1*, Ch. Niranjan Patra2 and Subasini Pattnaik3
1Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Hyderabad, India
2Roland Institute of Pharmaceutical Sciences, Khodashing, Berhampur, India.
3Department of Zoology, Berhampur University, Berhampur, India
*Corresponding Author
DOI No:

ABSTRACT:
Various Quinazolinone clubbed Pyrazole derivative compounds (7a1,7a2,7b1,7b2) were synthesized as per standard chemical procedure and characterized by physical and spectral analysis. Quinazolinone nucleus was synthesized using anthranilic acid as starting material and then it clubbed with Pyrazole moiety. The antimicrobial activity of all the synthesized compounds was evaluated separately for their possible antifungal activity against common pathogenic microorganisms Candida albicans and Aspergillus niger by cup plate method and anthelmintic activity by using common Indian earthworm Pheritima posthuma. Ketokonazole was used as a standard antifungal drug and albendazole, piperazine citrate as standard antihealmintic drug in this study.
KEYWORDS:
Pyrazole, Quinazolinone, Antifungal, Anthelmintic, Ketokonazole.
Cite:
Pratap Kumar Patra, Ch. Niranjan Patra, Subasini Pattnaik. Antifungal and Anthelmintic Activity of Some Novel Pyrazole Derivative. Asian J. Research Chem 7(1): January 2014; Page 92-98.
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