Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  1

Year :  2014

Pages :   07-10

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Multi-Component Mode UV Spectrophotometric Method for the Estimation of Metformin and Glimepiride in Combined Dosage Form



Address:   Atul Srivastav*, Shishir Maheshwari
Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, precise and specific UV spectrophotometric method for Multicomponent Mode of Metformin HCl and Metformin in combine dosage form has been developed. The wavelengths 233 nm and 228 nm were selected for the estimation of Metformin HCl and Glimepiride respectively, where Acetonitrile was used as solvent. Linearity were observed in the concentration range of 5-10 µg/ml (r2=0.999) and 3-18 µg/ml (r2=0.999) for Metformin HCl and Glimepiride. These methods were validated according to ICH guidelines.
KEYWORDS:
Metformin HCl, Glimepiride, Multicomponent mode.
Cite:
Atul Srivastav, Shishir Maheshwari. Development and Validation of Multi-Component Mode UV Spectrophotometric Method for the Estimation of Metformin and Glimepiride in Combined Dosage Form. Asian J. Research Chem. 7(1): January 2014; Page 07-10.
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