Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  1

Year :  2014

Pages :   33-40

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Pharmacological Evaluation of Synthesized Test Compounds of Quinazolinones and Pyrazolinones

Address:   Sk. Shaheda Sultana1*, P. Parveen1, P.Usha1,V. Vasu Naik1, Rajesh Akki1, M. Gayatri Ramya2
1Hindu College of Pharmacy, Amaravathi Road Guntur-522002
2University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522 510
*Corresponding Author

Evaluation of antimicrobial, antihelmentihic, analgesic, anti-inflammatory activity of Quinazolinones and Pyrazolinones. Antimicrobial activity is evaluated by the effectiveness of the compounds in this test is based on the size of the zone of inhibition. The zone of inhibition also depends on the diffusibility of synthesized compounds, the size of the inoculum, the type of medium and other factors. The concentrations of the synthesized compounds at the edge of zone of inhibition represent Minimal Inhibitory Concentration of synthesized compounds. Alternatively the synthesized compounds disc with different concentrations could be employed in the test. The MIC is the lowest concentration of antibiotic that exhibits the zone of inhibition on the assay plate. Antihelmenthic activity is evaluated by collecting earthworms and kept in to each petri plate containing drug solution at a time. The movement of the earth worms were observed. Time taken for the paralysis and death of the organism were noted. Analgesic activity is evaluated by administer of all the test compounds orally. Dip the tail tip of individual animals up to 5cm into hot water (maintained at 580c) , sixty minutes after oral administration of test compounds and 30 min after i.v. injection of morphine sulfate, and note the response time as the sudden withdrawal of the tail from the hot water.Anti inflammatory activity is evaluated by measuring the paw volume initially and at 1, 2, 3 and 4 hrs after histamine injection, using Plethysmograph. Our present research includes determining the effectiveness of synthesized products which is a mile stone of Indian industry for profitability and innovation.
Pharmacological Evaluation of Synthesized Test Compounds of Quinazolinones and Pyrazolinones.
Sk. Shaheda Sultana, P. Parveen, P.Usha, V. Vasu Naik, Rajesh Akki, M. Gayatri Ramya. Pharmacological Evaluation of Synthesized Test Compounds of Quinazolinones and Pyrazolinones. Asian J. Research Chem 7(1): January 2014; Page 33-40.
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