Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   310-315

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Anticancer Activity of Novel Substituted 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine and 1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine Derivatives



Address:   Deepak Kumar Basedia*, Birendra Shrivastava1, B. K. Dubey2, Pankaj Sharma1
1School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
2T.I.T. College of Pharmacy, Anand Nagar, BHEL, Bhopal, M.P., India.
*Corresponding Author
DOI No:

ABSTRACT:
A new class of heterocyclic compounds 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine and 1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine derivatives have been synthesized. The structures of these compounds have been confirmed by spectral analysis (IR, NMR & Mass). The title compounds were then evaluated for their In vitro cytotoxic activity by MTT assay method and NR assay method using breast cancer cell lines (MCF-7 and MDA MB 231). Newly synthesized compounds have shown promising anticancer activity.
KEYWORDS:
1,3,5-Triazine, In-vitro cytotoxic, Breast cancer, Cell lines MCF-7 and MDA MB 231.
Cite:
Deepak Kumar Basedia, Birendra Shrivastava, B. K. Dubey, Pankaj Sharma. Synthesis and Anticancer Activity of Novel Substituted 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine and 1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine Derivatives. Asian J. Research Chem. 7(3): March 2014; Page 310-315.
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