Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   327-334

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and Anti-fungal activity of Some Novel Heterofused Thienotriazines



Address:   H R Roopa*, J. Saravanan
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author
DOI No:

ABSTRACT:
2-amino-3-N-(substituted carboxanilido)-4, 5-disubstituted thiophenes 1a – 1h were synthesized using versatile Gewald reaction. First step is preparation of substituted cyanoacetanilides (Comp. No JSR a and b) which was carried out by Substituted anilines and Ethyl cyano acetate which was then reacted with Methylenic ketone, ammonium acetate, glacial acetic acid, benzene, sulphur to produce 2-amino-3-N-(substituted carboxanilido)-4, 5-disubstituted thiophenes JSR 1a–1h. Later the compound was subjected to diazotization to yield eight new thieno triazines. The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-fungal activity.
KEYWORDS:
Synthesis, Thiophenes, Thienotriazines, Spectral analysis, Antifungal activity.
Cite:
H R Roopa, J. Saravanan. Synthesis, Characterization and Anti-fungal activity of Some Novel Heterofused Thienotriazines. Asian J. Research Chem. 7(3): March 2014; Page 327-334.
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