Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   285-292

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis, Characterization and Anti-Inflammatory Activity of Some Novel Heterofused Thienotriazines



Address:   Roopa H.R.*, Saravanan J., Mohan S., Rekha Parmesh
Department of Pharmaceutical Chemistry, The PES College of Pharmacy, Hanumanthanagar, Bangalore.
*Corresponding Author
DOI No:

ABSTRACT:
The 2- amino (3-N-substituted carboxanilido)-4,5- di substituted thiophenes (JSR 1a-1h) was synthesized via a multicomponent condensation between sulphur, Ethyl methyl ketone and methoxy cyano acetanalide adapting Gewald reaction. Later it was diazotized to yield new compounds like thieno-1,2,3-triazin-4-ones (JSR2a-2h).The synthesized compounds were characterized by preliminary laboratory techniques like MP, TLC, IR and further confirmed by NMR and Mass spectra. The diazotized compounds (JSR2a-2h) were used for screening of in-vivo anti-inflammatory activity using Wistar rats. JSR2d, 2e and 2h showed the maximum reduction in paw volume of the rats and were found to be most significant compound and the compounds JSR-2a and 2c showed very mild anti-inflammatory activity and caused mild reduction in paw volume of the rats followed by JSR-2b, 2f and 2g.
KEYWORDS:
Synthesis, thiophenes, thienotriazines, Anti-inflammatory activity.
Cite:
Roopa H.R., Saravanan J., Mohan S., Rekha Parmesh. Synthesis, Characterization and Anti-Inflammatory Activity of Some Novel Heterofused Thienotriazines. Asian J. Research Chem. 7(3): March 2014; Page 285-292.
[View HTML]      [View PDF]



Visitor's No. :   127016