Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  4

Year :  2014

Pages :   407-411

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Gum acacia-acrylic acid hydrogels: pH sensitive materials for drug delivery system

Address:   Md Mateen M Shaikh1*, Madhubala S. Lonikar2, Shrikant V. Lonikar3
1Brahmdevdada Mane Institute of Technology, Belati, Solapur -413005
2Walchand Institute of Technology, Ashok Chowk, Solapur-413006
3School of Chemical Sciences, Solapur University, Kegaon, Solapur – 413255
*Corresponding Author

Graft copolymer hydrogels that are pH sensitive were synthesized by ceric ion initiated graft copolymerization of acrylic acid onto gum acacia in aqueous medium in the presence of varying amount of N, N–methylene bisacrylamide as a crosslinking agent. The copolymers were characterized by FTIR spectroscopy and swelling measurement. The swelling behavior was investigated as a function of pH. It was seen that as the amount of crosslinker increases the swelling properties decreases gradually and that the copolymers undergo a sharp volume phase transition with the change in pH of the swelling medium from an acid to an alkaline one. This can be attributed that the -COOH group present within network remains almost intact, moreover there exist strong H- bonding interaction between -COOH groups of acrylic acid and -CONH2 group of MBAm which are present within the network, thus resulting in movement of polymeric segment within the hydrogel. However, in the medium of pH 7.4 the complete ionization of COOH group result in extensive chain relaxation due to repulsion among similarly charged –COO groups present in macromolecule chain. This suggests that diffusion of the entrapped active agents will be greatly enhanced with a change in pH of the medium, thus making these copolymers as a potential candidate for the use in agriculture, biomedicine, pharmaceutics and controlled delivery of bioactive agents.
Gum acacia, acrylic acid, hydrogels, pH sensitive, drug delivery systems.
Md Mateen M Shaikh, Madhubala S. Lonikar, Shrikant V. Lonikar. Gum acacia-acrylic acid hydrogels: pH sensitive materials for drug delivery system. Asian J. Research Chem. 7(4): April 2014; Page 407-411.
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