Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  4

Year :  2014

Pages :   393-396

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Validated Simple UV Spectrophotometric Method for the Estimation of Pitavastatin in bulk and Pharmaceutical Dosage Form



Address:   Mohammad Yunoos*, M. Sowjanya, B. Sushma, K. Pavan Kumar
Department of Pharmaceutical Analysis, Bapatla College of Pharmacy, Bapatla-5222101, Andhra Pradesh, India
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, rapid and sensitive UV spectrophotometric method has been developed for the estimation of Pitavastatin (PVT) in bulk as well as in Pharmaceutical dosage forms. Pitavastatin is used as Anti-hyperlipidemic agent and HMG-CoA reductase inhibitor. It is available in the market in tablet dosage forms with strength 1mg, 2mg and 4mg. The present research work involves the estimation of Pitavastatin using 0.1N HCL as solvent. An absorption maximum (? max) was found to be 249.5nm. It obeys the Beer’s law in the concentration range of 2-12µg/ml with a correlation coefficient value of 0.9996. Validation of the method has been carried out statistically as per ICH guidelines and the results were found to be satisfactory. The result of mean % recovery was found to be 99.83 + 0.39 % for Pitavastatin which shows that the method was not affected by the presence of common excipients in tablet dosage form. The % RSD for both inter-day and intra-day precision was found to be less than 2%. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.122 µg/mL and 0.371 µg/mL. The method was validated by determining its sensitivity, linearity, accuracy and precision which proves suitability of the developed method for the routine quality control analysis for the estimation of Pitavastatin in bulk and tablet dosage form.
KEYWORDS:
Pitavastatin (PVT), Spectrophotometric method, Validation, ICH guidelines, tablet dosage form.
Cite:
Mohammad Yunoos, M. Sowjanya, B. Sushma, K. Pavan Kumar. A Validated Simple UV Spectrophotometric Method for the Estimation of Pitavastatin in bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 7(4): April 2014; Page 393-396.
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