Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  6

Year :  2014

Pages :   596-599

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV Spectrophotometric Method of Amlodipine Besylste in Bulk and Pharmaceutical Formulation



Address:   Raveendra Babu G.1*, Praveen Kumar J.2, Sri Lakshmi Surekha P.1, Kala Praveen T.1, Sambhasiva Rao P.3
1Department of Pharmaceutical Analysis, D.C.R.M. Pharmacy College, Inkollu-523167
2Analytical Research and Development, Laurus Labs Private Limited, Hyderabad-500082
3Department of Pharmaceutics, Vijaya College Pharmacy, Hayathnagar, Hyderabad-501511
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Amlodipine besylate in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 365nm.The percentage recovery of Amlodipine besylate ranged from (99.80 ± 1.09) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-25µg/ml having line equation y = Y=0.0163C - 0.00120 with correlation coefficient of 0.9999. Results of the analysis were validated statistically and by recovery study.
KEYWORDS:
Amlodipine besylate, UV Spectrophotometry, Validation, Beer’s law.
Cite:
Raveendra Babu G., Praveen Kumar J., Sri Lakshmi Surekha P., Kala Praveen T., Sambhasiva Rao P.. Development and Validation of UV Spectrophotometric Method of Amlodipine Besylste in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 7(6): June 2014; Page 596-599.
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