Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  6

Year :  2014

Pages :   561-564

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Simultaneous Determination of Paracetamol and Caffeine in tablets by Mean Centering and Derivative Transforms of UV Ratio Spectra



Address:   Vu Dang Hoang
Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam
*Corresponding Author
DOI No:

ABSTRACT:
Mean centering and first derivative transforms of UV ratio spectra were developed to resolve strongly overlapping spectra of paracetamol and caffeine in binary mixtures. Paracetamol 25 mg/L and caffeine 3.25 mg/L were identified as suitable divisors to obtain highest spectral recovery. The calibration graphs were recorded in phosphate buffer pH 7.2 for paracetamol (10–35 mg/L) and caffeine (2.4 – 4.4 mg/L). These spectrophotometric methods were successfully applied to the simultaneous determination of paracetamol and caffeine in commercially available tablets. They were also more sensitive than previously reported spectrophotometric method. No significant difference in accuracy and precision was observed for the proposed methods and official USP-HPLC.
KEYWORDS:
UV ratio spectra, Paracetamol, Caffeine, derivative, mean centering, tablets.
Cite:
Vu Dang Hoang. Simultaneous Determination of Paracetamol and Caffeine in tablets by Mean Centering and Derivative Transforms of UV Ratio Spectra. Asian J. Research Chem. 7(6): June 2014; Page 561-564.
[View HTML]      [View PDF]



Visitor's No. :   204337