Journal :   Asian Journal of Research in Chemistry

Volume No. :   7

Issue No. :  7

Year :  2014

Pages :   615-618

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Indapamide in Combined Pharmaceutical Dosage Form



Address:   Patel Meghna P. 1*, Hasumati Raj1, Shah Nehal2
1Research Scholar, RK University, Rajkot, India
1Assistant Professor, Shree Dhanvantary Pharmacy College, Kim, Gujarat, India
2 Principal, Dharmaj Degree Pharmacy College, Dharmaj, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, precise, rapid, economical UV spectrophotometry method namely first order derivative spectrophotometry have been developed and validated for estimation of Indapamide (IND) and Amlodipine besylate (AML) in combined tablet dosage form and can be used in routine analysis. In this method, the absorbance at 237.4 nm (ZCP of AML) and 241 nm (ZCP of IND) were used for estimation of IND and AML respectively. The method was found to be linear in the concentration range of 1.5-9 µg/ml for IND (r2=0.99983) and 5-30 µg/ml for AML (r2=0.99966). Mean assay was found to be 99.72% and 100.28% for IND and AML respectively.
KEYWORDS:
Indapamide (IND), Amlodipine besylate (AML), First order derivative spectrophotometry, Method Development, Validation, ICH guideline.
Cite:
Patel Meghna P., Hasumati Raj, Shah Nehal. First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Indapamide in Combined Pharmaceutical Dosage Form. Asian J. Research Chem. 7(7): July 2014; Page 615-618.
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