Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  2

Year :  2015

Pages :   99-107

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Determination of Protein Binding Affinities and Investigation into the Antimicrobial Activities of Cu(II), Co(II) and Ni(II) Mixed Ligand Complexes



Address:   Sameena Mehtab, Harpreet Parmar, Tanveer Irshad Siddiqi, Atanu Singha Roy
Department of Chemistry, Lovely Professional University, Jalandhar-Delhi G.T. Road, NH1, Phagwara, Punjab 144411, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00018.8

ABSTRACT:
The mixed ligand complexes (MLC) of Cu(II), Co(II) and Ni(II) ions with 1,10-phenanthroline (phen), glycine (gly) and tryptophan (trp) are synthesized and characterized. The interactions of these mixed ligand complexes with bovine serum albumin (BSA) have been investigated by fluorescence spectroscopy in combination with UV-VIS spectroscopy under physiological conditions. [Cu(gly)2phen] complex is able to quench to the fluorescence of bovine serum albumin (BSA) indicating the complexation between protein and ligand. The anti-microbial activities of all these complexes have been executed and good anti-microbial activities of the complexes over the ligands have been observed against the gram positive, gram negative bacteria and fungi.
KEYWORDS:
Mixed ligand complexes; Bovine serum albumin; Fluorescence quenching; Anti-microbial activity.
Cite:
Sameena Mehtab, Harpreet Parmar, Tanveer Irshad Siddiqi, Atanu Singha Roy. Determination of Protein Binding Affinities and Investigation into the Antimicrobial Activities of Cu(II), Co(II) and Ni(II) Mixed Ligand Complexes. Asian J. Research Chem 8(2): February 2015; Page 99-107.
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