Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  3

Year :  2015

Pages :   213-217

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and Anti-Inflammatory Activity of Some Schiff bases of 4-Amino-5,6-Dimethyl thieno [2,3-d] Pyrimidines



Address:   H.R. Roopa*, J. Saravanan, S. Mohan, Rekha Parmesh
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00038.3

ABSTRACT:
Schiff bases were synthesized by microwave irradiation method by using different substituted aldehydes with substituted thienopyrimidines. 4-Amino-5,6-dimethyl thieno [2,3-d] pyrimidine JSR-8 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step was preparation of 2-amino-3-cyano-4,5-dimethyl thiophene (JSR-D) which was carried out by condensation of diethylamine, ethylmethylketone, Malononitrile and sulphur then the solid obtained was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-dimethyl thieno [2,3-d] pyrimidine. Finally the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 8a-8k). The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-inflammatory activity.
KEYWORDS:
Synthesis, Thienopyrimidines, Schiff bases, Spectral analysis, Anti-inflammatory activity.
Cite:
H.R. Roopa, J. Saravanan, S. Mohan, Rekha Parmesh. Synthesis, Characterization and Anti-Inflammatory Activity of Some Schiff bases of 4-Amino-5,6-Dimethyl thieno [2,3-d] Pyrimidines. Asian J. Research Chem 8(3): March 2015; Page 213-217.
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