Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  3

Year :  2015

Pages :   161-164

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, characterization, and some metal complexes incorporating 4- chlorobenzaldimine 4- aminoantipyrine and 2-aminophenol in antimicrobial activity



Address:   Dilesh Indorkar*, O.P. Chourasia, S.N. Limaye
Department of Chemistry, Dr. H. S. Gour University (GDC Sausar) (A Central University), Sagar (M.P.)-470003
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00028.0

ABSTRACT:
Metal complexes of Schiff base (L) ligand, prepared via condensation of 4- chlorobenzaldimine 4- aminoantipyrine, and 2- aminophenol are prepared. The ligand is characterized based on elemental analysis, Mass, IR, and NMR spectra.Metal complexes are reported and characterized based on elemental analyses, IR, electronic spectra, magnetic moment,molar conductance and cyclic voltammetry (cv). From the elemental analyses, 1:1[M]:[Ligand] complexes are prepared with the general formulae [M(L CL) (M=Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)). The IR results demonstrate that coordination sites are the two azomethine nitrogen and hydroxyl oxygen atoms. The electronic spectral and magnetic measurement data indicate that the complexes exhibit tetra geometry and Cu(II) exhibits distorted square planar around the metal centre. The in vitro biological screening effects of the synthesized compounds were tested against various microbial species and the results show that the metal complexes are more biological active than the ligand. The DNA cleavage activity of the ligand and its complexes were assayed on pUC18 DNA using gel electrophoresis. The result shows that the Co(II) and Cu(II) complexes have completely cleaved the DNA.
KEYWORDS:
Electronic spectra, Antimicrobial, DNA, Ligand, Cyclic voltammetry.
Cite:
Dilesh Indorkar, O.P. Chourasia, S.N. Limaye. Synthesis, characterization, and some metal complexes incorporating 4- chlorobenzaldimine 4- aminoantipyrine and 2-aminophenol in antimicrobial activity. Asian J. Research Chem 8(3): March 2015; Page 161-164.
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