Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  3

Year :  2015

Pages :   170-174

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization of Some Novel Heterofused Thienopyrimidines for Anti-Inflammatory Activity



Address:   H.R. Roopa*, J. Saravanan, S. Mohan, Rekha Parmesh
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00030.9

ABSTRACT:
2-Amino-3-cyano-4, 5-disubstituted thiophene JSR-2 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step is preparation of 2-amino-3-cyano-4,5-disubstituted thiophene (JSR-c) which was carried out by condensation of diethylamine, cyclohexanone, Malononitrile and sulphur this compound was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-disubstituted thieno [2,3-d] pyrimidines. Then the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 7a-7k). The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-inflammatory activity.
KEYWORDS:
Synthesis, Thiophenes, Thienopyrimidines, Schiff bases, Spectral analysis, Anti-inflammatory activity.
Cite:
H.R. Roopa, J. Saravanan, S. Mohan, Rekha Parmesh. Synthesis, Characterization of Some Novel Heterofused Thienopyrimidines for Anti-Inflammatory Activity. Asian J. Research Chem 8(3): March 2015; Page 170-174.
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