Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  4

Year :  2015

Pages :   267-272

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Deriving Atom Economy Approach by Employing Dynamic Resolution of (3-Methoxy Phenyl)-(3-N, N-Dimethyl Amino)-2-Methyl Propanone



Address:   G. Venkanna1,2, G. Madhusudhan1*, K. Mukkanti2, K. Chandra Babu1, P. Venkateswarlu1
1Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO Company), 28A, IDA, Nacharam, Hyderabad 500 076, India
2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00046.2

ABSTRACT:
Racemic 3-Subsituted phenyl-3-(dimethylamino)-2-methylpropan-1-one resolved by means of a dynamic diastereomeric salt formation using di-Benzyl-L-tartaric acid with PTSA. The salts are formed in excellent yields and diastereomeric excesses.
KEYWORDS:
Tapentadol Hydrochloride, centrally acting analgesic, Dynamic resolution, Atom aconomy, asymmetric synthesis.
Cite:
G. Venkanna, G. Madhusudhan, K. Mukkanti, K. Chandra Babu, P. Venkateswarlu. Deriving Atom Economy Approach by Employing Dynamic Resolution of (3-Methoxy Phenyl)-(3-N, N-Dimethyl Amino)-2-Methyl Propanone. Asian J. Research Chem 8(4): April 2015; Page 267-272.
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