Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  6

Year :  2015

Pages :   399-406

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Docking Studies and Synthesis of Novel Flavones Screened for Biological Activities like Anticancer and Antioxidant Activity



Address:   Sushil Dagadu Patil2*, Kardele Vinayak2, Balsubraniyan1 and Shaikh Anwar2
1NIMS University, Jaipur
2Bhujbal Knowledge City, Department of Pharmaceutical Chemistry, MET Institute of Pharmacy, Adagaon, Nashik -422003India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00066.8

ABSTRACT:
Flavones are the derivatives of flavonoids, possessing the wider range of biological actions. A novel series of flavonoid Derivatives with the help of substituted benzaldehyde were synthesized and screened for biological activities like anticancer and antioxidant activity. All synthesized derivatives were screened for in-vitro cytotoxicity by Brine shrimp lethality assay in which 1-(2, 4- dihydroxyphenyl)-3-(4-(dimethyl amino) phenyl) prop-2ene-1one.(MCR-001) and 2-(4-(Di-methylamino) phenyl)-7-hydroxy-4-H-chromen-4-one. (MCR-002), 2-hydroxy-2-(4-(methyl (4-nitrostyryl) amino) phenyl)-4-oxochroman-7-yl benzoate. (MCR-004) and 2-(4-dimethyl amino) phenyl)-4-oxo-4H-chromen-7-yl benzoate. (MCR-005) showed highest anticancer activity as compared to 5-fluorouracil due to presence of hydroxy group. Among synthesized compounds, 4-nitro flavonoids compound derivatives were screened for antioxidant activity by using DPPH Scavenging Method. 2-(4-dimethyl amino) phenyl)-2-hydroxy 4-oxochroman-6-yl benzoate (MCR-005) showed highest antioxidant activity as compared to ascorbic acid. This work has revealed the scope and potential of flavonoids for future exploration to synthesize substituted flavonoids and chalcone derivatives by the use of different substituted benzaldehyde.
KEYWORDS:
Anti-cancer, antioxidant activity, 4-nitro flavonoids, substituted benzaldehyde.
Cite:
Sushil Dagadu Patil, Kardele Vinayak, Balsubraniyan, Shaikh Anwar. Docking Studies and Synthesis of Novel Flavones Screened for Biological Activities like Anticancer and Antioxidant Activity. Asian J. Research Chem 8(6): June 2015; Page 399-406.
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