Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  7

Year :  2015

Pages :   445-448

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Visible Spectroscopic Method for Estimation of Atenolol in Tablets



Address:   Raveendra Babu G.1*, Sivasai Kiran B2., Venkata Kumari M2., Sambasiva Rao P3., Madhuri P4.
1Department of Pharmaceutical Analysis, AKRG College of Pharmacy, Nallajrla-534112, A.P., India.
2 Department of Pharmaceutical Analysis, D.C.R.M. Pharmacy College, Inkollu-523167, A.P., India.
3Department of Pharmaceutics, Vijaya College Pharmacy, Hayathnagar, Hyderabad, Telangana, India.
4Department of Pharmaceutical Analysis, Vivekananda Group of Institutions, Batasingaram- 501511, Telengana, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00071.1

ABSTRACT:
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of atenolol in tablets. The method was based on the formation of colored chromogen (vanilline). The ?-max of atenolol was found to be 650nm to both crude and marketed sample and is analyzed using the beer-lamberts law. The percentage of recovery of atenolol ranged from (99.5 ± 0.16) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 2-10µg/ml having line equation Y=0. 2071C - 0.0043 with a correlation coefficient of 0.9999. The results of the analysis were validated statistically and by recovery study.
KEYWORDS:
Atenolol, Visible Spectrophotometry, Validation, Beer’s law, Method.
Cite:
Raveendra Babu, Sivasai Kiran B., Venkata Kumari M., Sambasiva Rao P, Madhuri P. Visible Spectroscopic Method for Estimation of Atenolol in Tablets. Asian J. Research Chem. 8(7): July- 2015 ; Page 445-448.
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