Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  7

Year :  2015

Pages :   465-470

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Lornoxicam and Eperisone in their Synthetic Mixture



Address:   Jawed Akhtar1*, Jatin Prajapati2, ShamimAhmad1, Mohammad Mujahid1, Gamal Osman Elhassan3
1Translam Institute of Pharmaceutical Education and Research, Meerut, Uttar Pradesh-250001
2Astra Life Care Pvt. Ltd, Ahmedabad.
3Faculty of Pharmacy, Omdruman Islamic University, Khartoum, Sudan
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00073.5

ABSTRACT:
A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of Lornoxicam (LXM) and Eperisone (EPE) by employing first order derivative zero crossing method in methanol. The first order derivative absorption at 264.5 nm (zero cross point of LXM) was used for quantification of EPE and 254 nm (zero cross point of EPE) for quantification of LXM. The linearity was established over the concentration range of 2-24 µg/ml with correlation coefficient 0.9987 and 0.997, respectively. The mean % recoveries were found to be in the range of 99.69 and 99.13 for LXM and EPE respectively. The developed method has been validated as per ICH guidelines and successfully applied to the estimation of LXM and EPE in their Synthetic Mixture.
KEYWORDS:
Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Lornoxicam and Eperisone in their Synthetic Mixture.
Cite:
Jawed Akhtar, Jatin Prajapati, ShamimAhmad, Mohammad Mujahid, Gamal Osman Elhassan. Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Lornoxicam and Eperisone in their Synthetic Mixture. Asian J. Research Chem. 8(7): July- 2015 ; Page 465-471.
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