Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  8

Year :  2015

Pages :   511-520

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Target Oriented Selective Synthesis of Antibacterial Active Tyrosinase Enzyme Inhibitor Coumarin Core Derivatives



Address:   Digambar Kumbhar1, Reshma Patil1, Dayanand Patil2, Ajinkya Patravale2, Dattatray Chandam2, Sunetra Jadhav1, Dattatray Chavan2, Prafulla Choudhari3, Manish Bhatia3, Madhukar Deshmukh1,2*
1Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, M.S., India
2Department of Chemistry, Shivaji University, Kolhapur, M.S., India
3Computational Drug Discovery Lab Department of Pharmaceutical Chemistry Bharati Vidyapeeth College of Pharmacy, Kolhapur, M.S., India
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00081.4

ABSTRACT:
Target oriented designs and selective synthesis of bioactive molecules with broad spectrum activity is a challenging job in the field of modern organic chemistry. Considering this opportunity herein, we report a highly competent selective synthesis of bioactive coumarin core derivative. Using computational drug design software only four selective antibacterial active derivatives was discovered and then synthesized. The efficiency of the synthesized compounds was scrutinized against bacterial pathogens such as P. vulgaris and B. megaterium. All the synthesized compounds showed better theoretical as well as practical results against selected pathogenic species. The minimum inhibitory concentration (MIC) values of the most active heterocycles were compared with that of ciprofloxacin. Results obtained in tyrocinase inhibition assay exactly correlate with MIC results and docking outcomes. The bioactivity of these type moieties provided a novel approach to develop new types of antibacterial drugs like entities effective against pathogens
KEYWORDS:
Docking simulation; Coumarin aldehyde; Cyclic 1, 3- diketone ; Acetic acid medium; Antibacterial activity; MIC, Tyrocinase inhibition assay.
Cite:
Digambar Kumbhar, Reshma Patil, Dayanand Patil, Ajinkya Patravale, Dattatray Chandam, Sunetra Jadhav, Dattatray Chavan, Prafulla Choudhari, Manish Bhatia, Madhukar Deshmukh. Target Oriented Selective Synthesis of Antibacterial Active Tyrosinase Enzyme Inhibitor Coumarin Core Derivatives. Asian J. Research Chem. 8(8): August 2015; Page 511-520.
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