Journal :   Asian Journal of Research in Chemistry

Volume No. :   8

Issue No. :  8

Year :  2015

Pages :   535-538

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Anticonvulsant Activity of 2, 4-Dinitrophenyl Hydrazones and Hydrazide-Hydrazones



Address:   Rajesh Vishnoi1, Mohammad Sabir2, Mahesh Kumar Gupta3 , M. P. Gupta4
1District Tuberculosis Centre, Kanpur, U.P., India-208001
2District Tuberculosis Centre, Kanpur Dehat, U.P., India- Pin Code - 209111
3P.K.S.S. Mahavidyalaya, Kanpur Dehat, U.P., India-209111
4Naiminath Homoeopathic Medical College, Hospital and Research Centre, Nawalpur, Agra-283202 (U.P.) India
*Corresponding Author
DOI No: 10.5958/0974-4150.2015.00085.1

ABSTRACT:
A number of aldehydes and ketones were condensed with 2,4-dinitro phenyl hydrazine to give corresponding 2,4-dinitrophenyl hydrazones (Ia-Ic). Again aldehydes and ketones were reacted with 2-phenylacetohydrazide to give hydrazide-hydrazones (IIa-IIc). Structure of synthesized compounds were confirmed by elemental analysis and spectral data. The synthesized compounds were evaluated for anticonvulsant activity in maximial electroshock seizure (MES) test using phenytoin as standard drug. In which compound IIa was found most potent among the series.
KEYWORDS:
Hydrazones, Hydrazide hydrazones, anticonvulsant activity, MES.
Cite:
Rajesh Vishnoi, Mohammad Sabir, Mahesh Kumar Gupta, M. P. Gupta. Synthesis and Anticonvulsant Activity of 2, 4-Dinitrophenyl Hydrazones and Hydrazide-Hydrazones. Asian J. Research Chem. 8(8): August 2015; Page 535-538.
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