Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  11

Year :  2016

Pages :   561-565

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Forced degradation study of Terbinafine HCl by HPLC with PDA detector

Address:   Tentu Nageswara Rao1*, Muralidhar Reddy Avuthu2, B. Venkata Reddy3, SNVS Murthy4
1Department of Chemistry, Krishna University, Machilipatnam, A.P., India.
2Department of Chemistry, SVKP & Dr. K.S Raju Arts & Science College, Penugonda, A.P, India.
3Department of Animal Science, Chonbuk National University, Jeonju, South Korea.
4Department of Chemistry, DLR PG College, G. Mamidada, AP India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00076.6

A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Terbinafine HCl and related impurities. The chromatographic separations were achieved on (150×4.6 mm), 5.0 µm make: YMC-Pack ODS-AM, 120A column employing Acetonitrile: methanol and Water pH 7.5, in the ratio of 20:10:10 v/v/v as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. Three impurities were eluted within 35 minutes. The detector wavelength of 230 nm was employed.
Forced degradation, HPLC, Method validation, Terbinafine.
Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy. Forced degradation study of Terbinafine HCl by HPLC with PDA detector. Asian J. Research Chem. 2016; 9(11): 561-565.
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