Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  11

Year :  2016

Pages :   561-565

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Forced degradation study of Terbinafine HCl by HPLC with PDA detector



Address:   Tentu Nageswara Rao1*, Muralidhar Reddy Avuthu2, B. Venkata Reddy3, SNVS Murthy4
1Department of Chemistry, Krishna University, Machilipatnam, A.P., India.
2Department of Chemistry, SVKP & Dr. K.S Raju Arts & Science College, Penugonda, A.P, India.
3Department of Animal Science, Chonbuk National University, Jeonju, South Korea.
4Department of Chemistry, DLR PG College, G. Mamidada, AP India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00076.6

ABSTRACT:
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Terbinafine HCl and related impurities. The chromatographic separations were achieved on (150×4.6 mm), 5.0 µm make: YMC-Pack ODS-AM, 120A column employing Acetonitrile: methanol and Water pH 7.5, in the ratio of 20:10:10 v/v/v as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. Three impurities were eluted within 35 minutes. The detector wavelength of 230 nm was employed.
KEYWORDS:
Forced degradation, HPLC, Method validation, Terbinafine.
Cite:
Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy. Forced degradation study of Terbinafine HCl by HPLC with PDA detector. Asian J. Research Chem. 2016; 9(11): 561-565.
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