Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  2

Year :  2016

Pages :   89-98

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and Biological Evaluation of Benzo[b][1,2,4]triazolo [4,3-d][1,4]diazepine Derivatives



Address:   V. Prabhakar1*, C. Divya Vani2, G. Govindu1
1 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu Andhra Pradesh, India
2Department of Chemistry, Sri Padmavati Women’s Degree and PG College, Tirupati, Andhra Pradesh, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00017.1

ABSTRACT:
Heterocyclic compounds occur widely in nature and quite a few of these are essential to life processes. The literature on heterocyclic compounds is replete with examples of a large number of synthetic methods of naturally occurring systems which are pharmacologically active. The heterocyclic compounds containing nitrogen has expanded exponentially in the past decades due to their unique physical properties, specific chemical reactivity and their remarkable potential biological activities. A survey of literature on the nitrogen heterocyclic reveal that dia zepines are important constituents of a wide variety of natural products with pharmacodynamic application. The Structures of the Synthesized Compounds are Confirmed by IR,1H NMR and 13C NMR Spectral data, Elemental Analysis, Mass spectral data. The compounds are also evaluated for their anti Oxidant activity by DPPH method, among them 13e and 13d are found as potent activity. The reaction proceeds efficiently under ambient conditions with good-to-excellent yields.
KEYWORDS:
Benzo diazepines, synthesis, Anti oxidant Activity, Biological importance, DPPH.
Cite:
V. Prabhakar, C. Divya Vani, G. Govindu. Synthesis, Characterization and Biological Evaluation of Benzo[b][1,2,4]triazolo [4,3-d][1,4]diazepine Derivatives. Asian J. Research Chem. 9(2): Feb., 2016; Page 89-98.
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