Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  3

Year :  2016

Pages :   101-106

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis, Characterization of 3-Chloro 4-(4- Substituted Phenyl -1- (4- Nitro Phenylazetidin -2-one by Microwave Method and Evaluation of Their Antibacterial Activity



Address:   Y. Pradeep Kumar1*, S. Chand Basha1, K. Anusha2, K. Madhuri2, C. Gopinath3
1Asst. Professor, Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115.
2Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115.
3HOD, Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115.
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00018.3

ABSTRACT:
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis was a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2- azetidinones is developed. This method has been assessed as greener methodology. In our present study, A series of six novel 2-azetidinones were synthesized, compounds were identified by melting point and thin layer chromatography , functional groups of synthesized compounds were confirmed by IR spectroscopy, compounds were evaluated for their antimicrobial activities. The activities were due to cyclic carbonyl group in 2-azetidinones. Some of the compounds have shown comparative antimicrobial activities against all the microbial strains.
KEYWORDS:
Microwave synthesis, 2-Azetedinone, Anti bacterial activity.
Cite:
Y. Pradeep Kumar, S. Chand Basha, K. Anusha, K. Madhuri, C. Gopinath. Synthesis, Characterization of 3-Chloro 4-(4- Substituted Phenyl -1- (4- Nitro Phenylazetidin -2-one by Microwave Method and Evaluation of Their Antibacterial Activity. Asian J. Research Chem. 9(3): Mar., 2016; Page 101-106.
[View HTML]      [View PDF]



Visitor's No. :   106359