Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  4

Year :  2016

Pages :   153-158

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Microwave Assisted Synthesis and Antimicrobial Screening of Heterocyclic Compounds Comprising of Thiazolidinone Ring



Address:   Chetan M. Bhalgat1,2*, Prasad P. Talekar1*, Puttaraj C.2, B. Ramesh2
1API-R&D, Integrated Product Development, Cipla Ltd, Patalaganga, Mumbai 410220
2Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G. Nagara- 571448, Mandya.
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00025.0

ABSTRACT:
In our earlier research, we have reported conventional synthesis and antioxidant activity of thiazolidinone derivatives. During various literature surveys, we found microwave technique is advantageous over conventional synthesis and various derivatives comprising of thiazolidinone group have shown good antimicrobial activity. By considering all these assumption, we have resynthesized our reported products by microwave synthesis and screened them for antimicrobial activity. The microwave assisted synthesis was found advantageous over conventional by reducing reaction time, increasing yield and lesser usage of solvent. Structures of all the synthesized compounds were confirmed by IR, 1H NMR, and mass spectral data. The synthesized compounds were evaluated for their antimicrobial activity. Few compounds were found with potent antimicrobial activity.
KEYWORDS:
Thiazole, Thiazolidinone, Microwave synthesis, Schiff’s bases, Antbacterial activity, Antifungal activity.
Cite:
Chetan M. Bhalgat, Prasad P. Talekar, Puttaraj C., B. Ramesh. Microwave Assisted Synthesis and Antimicrobial Screening of Heterocyclic Compounds Comprising of Thiazolidinone Ring. Asian J. Research Chem. 9(4): April, 2016; Page 153-158.
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