Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  4

Year :  2016

Pages :   159-169

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Anti - microbial Activity of Novel Isoxazoline Mannich base Derivatives containing Carbazole Ring



Address:   V. Prabhakar1*, K. Sudhakar Babu1, L.K. Ravindranath1, P. V. Ramana Reddy2, J. Latha3
1Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, (A P) India.
2Department of Chemistry, Loyola Degree College, Sri Yogivemana University, Kadapa , (A P) India.
3Department of Bio-Technology, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Anantapuramu – 515003 (A.P) India
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00026.2

ABSTRACT:
A Novel Series of Compounds were synthesized by Condensation reaction of Carbazole aldehyde with Substituted Acetophenone derivatives 4 (a-d) in presence of alcoholic Sodium hydroxide Solution to get Chalcone Intermediates 5 (a-d), which were further treated hydroxyl amine hydrochloride in presence of Pyridine to get Iso Oxazoline Derivatives 6 (a-d). The latter were refluxed with Substituted Primary amines and formaldehyde for 8-10 hrs to get Mannich bases. The Structures of new compounds were confirmed by IR and 1H NMR and 13C NMR Spectral Data. Anti-bacterial and Anti-fungal Activities were evaluated and compared with the standard drugs, some compounds of the series Exhibited Promising Anti-microbial and Anti-fungal Activity Compared to Standard Drugs.
KEYWORDS:
Chalcone, Isoxazoline, Carbazoles, Mannich Bases, Anti-bacterial, Antifungal Activity.
Cite:
V. Prabhakar, K. Sudhakar Babu, L.K. Ravindranath, P. V. Ramana Reddy, J. Latha. Synthesis and Anti - microbial Activity of Novel Isoxazoline Mannich base Derivatives containing Carbazole Ring. Asian J. Research Chem. 9(4): April, 2016; Page 159-169.
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