Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  8

Year :  2016

Pages :   366-368

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of RP-HPLC Method for Simultaneous Estimation of Naproxen and Esomeprazole in Pharmaceutical Dosage Form



Address:   Haritha Gali1, Vishwanadham Yerragunta2*
1Department of Pharmaceutical Analysis, PNR College of Pharmacy, Shamshabad, RR Dt., Telangana, India.
2Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak Dt, Telangana, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00055.9

ABSTRACT:
The objective of the study was to develop a simple, accurate, precise RP-HPLC method for the determination of Esomeprazole and Naproxen using mobile phase (A mixture of Acetonitrile and Methanol in the ratio of 60:40 was considered to be the optimal composition of solvent) as the solvent. The proposed method was involves the measurement of retention time at selected analytical wavelength 260.0 nm was selected as the analytical wavelength. The retention time of Esomeprazole and Naproxen was found to be 3.425 and 4.352. The linearity of the proposed method was in the range of r = 0.9999 for Esomeprazole and r = 0.9999 for Naproxen. The method was statistically validated for its linearity, accuracy and precision of the formulation.
KEYWORDS:
Esomeprazole, Naproxen, RP-HPLC method.
Cite:
Haritha Gali, Vishwanadham Yerragunta. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Naproxen and Esomeprazole in Pharmaceutical Dosage Form. Asian J. Research Chem. 2016; 9(8): 366-368.
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